...Definitive Management of Oral Mucositis
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 How ProThelial™ Works


PROTHELIAL™ DEVICE MECHANISM OF ACTION – FOR MUCOSA-BASED PAIN, NAUSEA, 
VOMITING & DIARRHEA
The surface “pockets” of restrictive micro-environs created by ProThelial’s unique 
layering probably affect the flux of ions across mucosal receptors responsible for 
pain, nausea, vomiting and neuro-secretory diarrhea. These specialized mucosal receptors 
triggered by chemoradiation maintain their state of activation by means of gated-ion 
fluxes across surface membranes that face the lumen of the gut. It is probable that the 
same restrictive micro-environs that crowd growth factors to the vicinity of their 
receptors also affect the surrounding space available to membranes for ion-flux and 
exchange. Spatial limitation of the immediate surface environment surrounding ion-gated 
receptors along the GI tract impact the receptor’s ability to perpetuate the ion fluxes 
required to keep the receptor “turned on” or stimulated. Physically restrictive 
micro-environs surrounding membranes of stimulated receptors exhaust the ions immediately 
available to it. This limits the ability of the receptor to stay “on”. The result is the 
quiescence of the membrane and the reduction of receptor-associated pain, nausea 
(thereby vomiting) and neurosecretory diarrhea, all of which are triggered by 
chemoradiation therapy.







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